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5icm

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==17beta-hydroxysteroid dehydrogenase type 14 in complex with a non-steroidal inhibitor==
==17beta-hydroxysteroid dehydrogenase type 14 in complex with a non-steroidal inhibitor==
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<StructureSection load='5icm' size='340' side='right' caption='[[5icm]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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<StructureSection load='5icm' size='340' side='right'caption='[[5icm]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5icm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ICM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5icm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ICM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F45:[6-(3,4-DIHYDROXYPHENYL)PYRIDIN-2-YL](4-FLUORO-3-HYDROXYPHENYL)METHANONE'>F45</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5en4|5en4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F45:[6-(3,4-DIHYDROXYPHENYL)PYRIDIN-2-YL](4-FLUORO-3-HYDROXYPHENYL)METHANONE'>F45</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5icm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icm OCA], [http://pdbe.org/5icm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icm RCSB], [http://www.ebi.ac.uk/pdbsum/5icm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5icm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5icm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icm OCA], [https://pdbe.org/5icm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5icm RCSB], [https://www.ebi.ac.uk/pdbsum/5icm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5icm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
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[https://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5icm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5icm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bertoletti, N]]
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[[Category: Homo sapiens]]
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[[Category: Braun, F]]
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[[Category: Large Structures]]
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[[Category: Heine, A]]
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[[Category: Bertoletti N]]
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[[Category: Klebe, G]]
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[[Category: Braun F]]
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[[Category: Marchais-Oberwinkler, S]]
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[[Category: Heine A]]
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[[Category: Hydroxysteroid dehydrogenase]]
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[[Category: Klebe G]]
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[[Category: Inhibitor complex]]
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[[Category: Marchais-Oberwinkler S]]
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[[Category: Oxidoreductase]]
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Current revision

17beta-hydroxysteroid dehydrogenase type 14 in complex with a non-steroidal inhibitor

PDB ID 5icm

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