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4u93

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==Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990==
==Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990==
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<StructureSection load='4u93' size='340' side='right' caption='[[4u93]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4u93' size='340' side='right'caption='[[4u93]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U93 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u93]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U93 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=990:(7R)-2-AMINO-7-[4-FLUORO-2-(6-METHOXYPYRIDIN-2-YL)PHENYL]-4-METHYL-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE'>990</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u93 OCA], [http://pdbe.org/4u93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u93 RCSB], [http://www.ebi.ac.uk/pdbsum/4u93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u93 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=990:(7R)-2-AMINO-7-[4-FLUORO-2-(6-METHOXYPYRIDIN-2-YL)PHENYL]-4-METHYL-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE'>990</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u93 OCA], [https://pdbe.org/4u93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u93 RCSB], [https://www.ebi.ac.uk/pdbsum/4u93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u93 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bellamacina, C R]]
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[[Category: Homo sapiens]]
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[[Category: Bussiere, D]]
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[[Category: Large Structures]]
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[[Category: Shafer, C M]]
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[[Category: Bellamacina CR]]
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[[Category: Atp-binding domain]]
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[[Category: Bussiere D]]
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[[Category: Chaperone]]
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[[Category: Shafer CM]]

Current revision

Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990

PDB ID 4u93

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