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5cfb

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==Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine==
==Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine==
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<StructureSection load='5cfb' size='340' side='right' caption='[[5cfb]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
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<StructureSection load='5cfb' size='340' side='right'caption='[[5cfb]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cfb]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cfb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SY9:STRYCHNINE'>SY9</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfb OCA], [http://pdbe.org/5cfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfb RCSB], [http://www.ebi.ac.uk/pdbsum/5cfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfb ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SY9:STRYCHNINE'>SY9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfb OCA], [https://pdbe.org/5cfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfb RCSB], [https://www.ebi.ac.uk/pdbsum/5cfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN]] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
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[https://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, H]]
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[[Category: Homo sapiens]]
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[[Category: Huang, X]]
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[[Category: Large Structures]]
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[[Category: Shaffer, P L]]
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[[Category: Chen H]]
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[[Category: Cys-loop receptor]]
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[[Category: Huang X]]
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[[Category: Ligand-gated ion channel]]
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[[Category: Shaffer PL]]
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[[Category: Membrane protein]]
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[[Category: Neurotransmitter receptor]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine

PDB ID 5cfb

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