1k12

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[[Image:1k12.gif|left|200px]]
 
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{{Structure
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==Fucose Binding lectin==
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|PDB= 1k12 |SIZE=350|CAPTION= <scene name='initialview01'>1k12</scene>, resolution 1.90&Aring;
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<StructureSection load='1k12' size='340' side='right'caption='[[1k12]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
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<table><tr><td colspan='2'>[[1k12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anguilla_anguilla Anguilla anguilla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K12 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k12 OCA], [https://pdbe.org/1k12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k12 RCSB], [https://www.ebi.ac.uk/pdbsum/1k12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k12 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k12 OCA], [http://www.ebi.ac.uk/pdbsum/1k12 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k12 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/FUCL_ANGAN FUCL_ANGAN] Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.<ref>PMID:15207656</ref> <ref>PMID:12091873</ref>
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== Evolutionary Conservation ==
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'''Fucose Binding lectin'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/1k12_consurf.spt"</scriptWhenChecked>
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Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1K12 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anguilla_anguilla Anguilla anguilla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K12 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k12 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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A novel fucose recognition fold involved in innate immunity., Bianchet MA, Odom EW, Vasta GR, Amzel LM, Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12091873 12091873]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Anguilla anguilla]]
[[Category: Anguilla anguilla]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Amzel, L M.]]
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[[Category: Amzel LM]]
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[[Category: Bianchet, M A.]]
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[[Category: Bianchet MA]]
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[[Category: Odom, E W.]]
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[[Category: Odom EW]]
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[[Category: Vasta, G R.]]
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[[Category: Vasta GR]]
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[[Category: beta barrel]]
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[[Category: protein carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:52 2008''
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Current revision

Fucose Binding lectin

PDB ID 1k12

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