5e61

<StructureSection load='5e61' size='340' side='right' caption='[[5e61]], [[Resolution|resolution]] 1.79&Aring;' scene=''>

<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E61 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e5v|5e5v]], [[5e5x|5e5x]], [[5e5z|5e5z]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [http://pdbe.org/5e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [http://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register beta sheets, that may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in Islet amyloid polypeptide (IAPP), whose amyloidogenic properties are associated with Type 2 Diabetes. We determined four new crystal structures of segments within IAPP all forming steric zippers. Most interestingly, one of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. Our results provide evidence that out-of-register beta sheets may be a common structural motif in amyloid aggregates and may be associated with toxicity.

Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.,Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D J Phys Chem B. 2015 Dec 2. PMID:26629790<ref>PMID:26629790</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 5e61" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Eisenberg, D]]

[[Category: Soriaga, A B]]

[[Category: Amyloid-like protofibril]]

[[Category: De novo protein]]

[[Category: Protein fibril]]