1k19

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[[Image:1k19.jpg|left|200px]]
 
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{{Structure
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==NMR Solution Structure of the Chemosensory Protein CSP2 from Moth Mamestra brassicae==
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|PDB= 1k19 |SIZE=350|CAPTION= <scene name='initialview01'>1k19</scene>
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<StructureSection load='1k19' size='340' side='right'caption='[[1k19]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1k19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mamestra_brassicae Mamestra brassicae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K19 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k19 OCA], [https://pdbe.org/1k19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k19 RCSB], [https://www.ebi.ac.uk/pdbsum/1k19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k19 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k19 OCA], [http://www.ebi.ac.uk/pdbsum/1k19 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k19 RCSB]</span>
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[https://www.uniprot.org/uniprot/Q9NG96_MAMBR Q9NG96_MAMBR]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''NMR Solution Structure of the Chemosensory Protein CSP2 from Moth Mamestra brassicae'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/1k19_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Chemosensory proteins (CSPs) are believed to be involved in chemical communication and perception. A number of such proteins, of molecular mass approximately 13 kDa, have been isolated from different sensory organs of a wide range of insect species. Several CSPs have been identified in the antennae and proboscis of the moth Mamestra brassicae. CSPMbraA6, a 112-amino-acid antennal protein, has been expressed in a soluble form in large quantities in the Escherichi coli periplasm. NMR structure determination of CSPMbraA6 has been performed with 1H- and 15N-labelled samples. The calculated structures present an average root mean square deviation about the mean structure of 0.63 A for backbone atoms and 1.27 A for all non-hydrogen atoms except the 12 N-terminal residues. The protein is well folded from residue 12 to residue 110, and consists of a non-bundle alpha-helical structure with six helices connected by alpha alpha loops. It has a globular shape, with overall dimensions of 32 A x 28 A x 24 A. A channel is visible in the hydrophobic core, with dimensions of 3 A x 9 A x 21 A. In some of the 20 solution structures calculated, this channel is closed either by Trp-94 at one end or by Tyr-26 at the other end; in some other solutions, this channel is closed at both ends. Binding experiments with 12-bromododecanol indicate that the CSPMbraA6 structure is modified upon ligand binding.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k19 ConSurf].
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1K19 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mamestra_brassicae Mamestra brassicae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K19 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Solution structure of a chemosensory protein from the moth Mamestra brassicae., Mosbah A, Campanacci V, Lartigue A, Tegoni M, Cambillau C, Darbon H, Biochem J. 2003 Jan 1;369(Pt 1):39-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12217077 12217077]
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[[Category: Large Structures]]
[[Category: Mamestra brassicae]]
[[Category: Mamestra brassicae]]
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[[Category: Single protein]]
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[[Category: Cambillau C]]
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[[Category: Cambillau, C.]]
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[[Category: Campanacci V]]
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[[Category: Campanacci, V.]]
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[[Category: Darbon H]]
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[[Category: Darbon, H.]]
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[[Category: Lartigue A]]
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[[Category: Lartigue, A.]]
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[[Category: Mosbah A]]
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[[Category: Mosbah, A.]]
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[[Category: Tegoni M]]
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[[Category: Tegoni, M.]]
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[[Category: chemosensory]]
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[[Category: nmr]]
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[[Category: pheromone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:56 2008''
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Current revision

NMR Solution Structure of the Chemosensory Protein CSP2 from Moth Mamestra brassicae

PDB ID 1k19

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