1k2j
From Proteopedia
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| - | [[Image:1k2j.gif|left|200px]] | ||
| - | + | ==NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2== | |
| - | + | <StructureSection load='1k2j' size='340' side='right'caption='[[1k2j]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1k2j]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K2J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2j OCA], [https://pdbe.org/1k2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k2j RCSB], [https://www.ebi.ac.uk/pdbsum/1k2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k2j ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | <div style="background-color:#fffaf0;"> | |
| - | + | == Publication Abstract from PubMed == | |
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Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed. | Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed. | ||
| - | + | Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2).,Lam SL, Ip LN J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:11922844<ref>PMID:11922844</ref> | |
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| - | Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2)., Lam SL, Ip LN | + | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 1k2j" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ip LN]] | ||
| + | [[Category: Lam SL]] | ||
Current revision
NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2
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