4wtv

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==Crystal structure of the phosphatidylinositol 4-kinase IIbeta==
==Crystal structure of the phosphatidylinositol 4-kinase IIbeta==
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<StructureSection load='4wtv' size='340' side='right' caption='[[4wtv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4wtv' size='340' side='right'caption='[[4wtv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wtv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WTV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wtv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WTV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wtv OCA], [http://pdbe.org/4wtv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wtv RCSB], [http://www.ebi.ac.uk/pdbsum/4wtv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wtv ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wtv OCA], [https://pdbe.org/4wtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wtv RCSB], [https://www.ebi.ac.uk/pdbsum/4wtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wtv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/P4K2B_HUMAN P4K2B_HUMAN]] Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<ref>PMID:11923287</ref>
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[https://www.uniprot.org/uniprot/P4K2B_HUMAN P4K2B_HUMAN] Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<ref>PMID:11923287</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4wtv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4wtv" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baumlova, A]]
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[[Category: Escherichia virus T4]]
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[[Category: Boura, E]]
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[[Category: Homo sapiens]]
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[[Category: Chalupska, D]]
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[[Category: Large Structures]]
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[[Category: Klima, M]]
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[[Category: Baumlova A]]
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[[Category: Hydrolase]]
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[[Category: Boura E]]
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[[Category: Lipid kinase]]
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[[Category: Chalupska D]]
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[[Category: Phosphatidyl inositol]]
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[[Category: Klima M]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the phosphatidylinositol 4-kinase IIbeta

PDB ID 4wtv

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