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2nar

From Proteopedia

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Current revision (07:04, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2nar is ON HOLD until Paper Publication
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==Solution structure of AVR3a_60-147 from Phytophthora infestans==
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<StructureSection load='2nar' size='340' side='right'caption='[[2nar]]' scene=''>
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Authors: Matena, A., Bayer, P., Zhukov, I., Stanek, J., Kozminski, W., van West, P., Wawra, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2nar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_infestans Phytophthora infestans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NAR FirstGlance]. <br>
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Description: Solution structure of AVR3a_60-147 from Phytophthora infestans
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nar OCA], [https://pdbe.org/2nar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nar RCSB], [https://www.ebi.ac.uk/pdbsum/2nar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nar ProSAT]</span></td></tr>
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[[Category: Zhukov, I]]
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</table>
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[[Category: Bayer, P]]
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== Function ==
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[[Category: Kozminski, W]]
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[https://www.uniprot.org/uniprot/A3AKI_PHYIN A3AKI_PHYIN] Multifunctional effector that can suppress host BAK1/SERK3-mediated immunity through at least two different pathways (PubMed:19794118, PubMed:20457921, PubMed:21348873, PubMed:26348328). Manipulates plant immunity by targeting and stabilizing host E3 ligase CMPG1. Preventing the normal 26S proteasome-dependent degradation of potato CMPG1, and thus potentially of its protein substrates in the host cell, further abolishes host cell death during the biotrophic phase of infection (PubMed:19794118, PubMed:20457921, PubMed:21348873). Associates also with the dynamin-related protein 2 (DRP2), a plant GTPase involved in immune receptor-mediated endocytosis (PubMed:26348328). The Avr3A(KI) form is recognized by R3a which triggers R3a-mediated hypersensitivity and suppresses INF1-induced cell death (PubMed:15894622, PubMed:16965554, PubMed:19245321).<ref>PMID:15894622</ref> <ref>PMID:16965554</ref> <ref>PMID:19245321</ref> <ref>PMID:19794118</ref> <ref>PMID:20457921</ref> <ref>PMID:21348873</ref> <ref>PMID:26348328</ref>
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[[Category: Matena, A]]
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== References ==
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[[Category: Wawra, S]]
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<references/>
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[[Category: Van West, P]]
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__TOC__
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[[Category: Stanek, J]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Phytophthora infestans]]
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[[Category: Bayer P]]
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[[Category: Kozminski W]]
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[[Category: Matena A]]
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[[Category: Stanek J]]
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[[Category: Wawra S]]
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[[Category: Zhukov I]]
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[[Category: Van West P]]

Current revision

Solution structure of AVR3a_60-147 from Phytophthora infestans

PDB ID 2nar

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