5kya
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5kya is ON HOLD Authors: Chen, G., McKeever, B.M. Description: Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrro...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core== | |
| + | <StructureSection load='5kya' size='340' side='right'caption='[[5kya]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5kya]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KYA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.598Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Y4:[2-[(6~{R})-2-(3-METHYLSULFONYLPHENYL)-6-PROPAN-2-YL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-YL]-4-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL'>6Y4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kya OCA], [https://pdbe.org/5kya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kya RCSB], [https://www.ebi.ac.uk/pdbsum/5kya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kya ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RXRB_HUMAN RXRB_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA). | ||
| - | + | ==See Also== | |
| - | + | *[[Liver X receptor|Liver X receptor]] | |
| - | + | *[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Chen | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen G]] | ||
| + | [[Category: McKeever BM]] | ||
Current revision
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core
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