5j4a
From Proteopedia
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==CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein== | ==CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein== | ||
| - | <StructureSection load='5j4a' size='340' side='right' caption='[[5j4a]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='5j4a' size='340' side='right'caption='[[5j4a]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5j4a]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4A OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5j4a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J4A FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4a OCA], [https://pdbe.org/5j4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j4a RCSB], [https://www.ebi.ac.uk/pdbsum/5j4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4a ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CDIA9_BURPE CDIA9_BURPE] Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. The C-terminal 160 residues (CT domain) acts as a general tRNA nuclease, and inhibits growth in E.coli. Cleaves specifically within the T-loop of E.coli tRNA2(Arg). Toxic activity is neutralized by coexpression of the cognate immunity protein CdiI in E.coli, but not by non-cognate immunity proteins from other strains of B.pseudomallei.<ref>PMID:22435733</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Burkholderia pseudomallei]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Goulding CW]] |
| - | [[Category: | + | [[Category: Johnson PM]] |
| - | + | ||
| - | + | ||
Current revision
CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein
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