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5lik

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==Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK181==
==Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK181==
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<StructureSection load='5lik' size='340' side='right' caption='[[5lik]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='5lik' size='340' side='right'caption='[[5lik]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lik]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LIK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LIK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=W8X:{2-[(4-BROMOBENZYL)CARBAMOYL]-5-CHLOROPHENOXY}ACETIC+ACID'>W8X</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=W8X:{2-[(4-BROMOBENZYL)CARBAMOYL]-5-CHLOROPHENOXY}ACETIC+ACID'>W8X</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lik OCA], [http://pdbe.org/5lik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lik RCSB], [http://www.ebi.ac.uk/pdbsum/5lik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lik ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lik OCA], [https://pdbe.org/5lik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lik RCSB], [https://www.ebi.ac.uk/pdbsum/5lik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lik ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lik" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lik" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cousido-Siah, A]]
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[[Category: Homo sapiens]]
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[[Category: Fanfrlik, J]]
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[[Category: Large Structures]]
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[[Category: Hobza, P]]
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[[Category: Cousido-Siah A]]
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[[Category: Kamlar, M]]
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[[Category: Fanfrlik J]]
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[[Category: Mitschler, A]]
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[[Category: Hobza P]]
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[[Category: Podjarny, A]]
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[[Category: Kamlar M]]
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[[Category: Ruiz, F X]]
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[[Category: Mitschler A]]
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[[Category: Vesely, J]]
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[[Category: Podjarny A]]
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[[Category: Aldo-keto reductase]]
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[[Category: Ruiz FX]]
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[[Category: Alpha-beta tim barrel]]
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[[Category: Vesely J]]
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[[Category: Cytosol]]
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[[Category: Halogenated ligand]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK181

PDB ID 5lik

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