Pseudoazurin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='340' side='right' caption='Structure of pseudoazurin complex with Cu+2 ion (orange) (PDB code [[1pza]]).' scene='59/593961/Cv/1'> |
== Function == | == Function == | ||
'''Pseudoazurin''' (PAZ) transfers electrons to and from nitrite reductase. PAZ is found in denitrifying bacteria. PAZ contains a single copper atom<ref>PMID:20945335</ref>. | '''Pseudoazurin''' (PAZ) transfers electrons to and from nitrite reductase. PAZ is found in denitrifying bacteria. PAZ contains a single copper atom<ref>PMID:20945335</ref>. | ||
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| + | == Structural highlights == | ||
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| + | The <scene name='59/593961/Cv/4'>PAZ copper is bound in a approximately tetrahedral geometry</scene>.<ref>PMID:8034003</ref>. | ||
</StructureSection> | </StructureSection> | ||
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[[1pzc]] – AfPAZ – ''Alcaligenes faecalis'' <br /> | [[1pzc]] – AfPAZ – ''Alcaligenes faecalis'' <br /> | ||
| - | [[1paz]], [[1pza]], [[1pzb]], [[3paz]] – AfPAZ + Cu+2 <br /> | + | [[1paz]], [[1pza]], [[1pzb]], [[3paz]], [[5x31]] – AfPAZ + Cu+2 <br /> |
[[3nyk]] – AfPAZ + Co+2 <br /> | [[3nyk]] – AfPAZ + Co+2 <br /> | ||
[[4paz]], [[5paz]], [[6paz]], [[7paz]], [[8paz]] – AfPAZ (mutant) + Cu+2 <br /> | [[4paz]], [[5paz]], [[6paz]], [[7paz]], [[8paz]] – AfPAZ (mutant) + Cu+2 <br /> | ||
| + | [[4rh4]] - AfPAZ + Zn+2<br /> | ||
[[4rh4]] – AfPAZ (mutant) + Zn+2 <br /> | [[4rh4]] – AfPAZ (mutant) + Zn+2 <br /> | ||
[[1py0]] – AfPAZ (mutant) + Zn+2 + Y+2<br /> | [[1py0]] – AfPAZ (mutant) + Zn+2 + Y+2<br /> | ||
[[2p80]] – AfPAZ + Cu+2 + Cu-containing nitrite reductase - NMR<br /> | [[2p80]] – AfPAZ + Cu+2 + Cu-containing nitrite reductase - NMR<br /> | ||
| - | [[1zia]], [[1zib]], [[1bqk]], [[1bqr]], [[2ux6]], [[2ux7]], [[2uxf]], [[2uxg]] – AcPAZ + Cu+2 – ''Achromobacter cycloclastes''<br /> | + | [[1zia]], [[1zib]], [[1bqk]], [[1bqr]], [[2ux6]], [[2ux7]], [[2uxf]], [[2uxg]], [[4yl4]] – AcPAZ + Cu+2 – ''Achromobacter cycloclastes''<br /> |
| - | [[2jkw]] – AcPAZ (mutant) + Cu+2 <br /> | + | [[2jkw]], [[8wqz]], [[5xmo]], [[5y23]], [[5ysg]], [[5yw3]], [[5z0x]], [[5ztd]], [[6akn]], [[6ifp]] – AcPAZ (mutant) + Cu+2 <br /> |
[[3ef4]] – PAZ + Cu+2 – ''Hyphomicrobium denitrificans''<br /> | [[3ef4]] – PAZ + Cu+2 – ''Hyphomicrobium denitrificans''<br /> | ||
[[1adw]], [[3erx]], [[4bwt]] – PpPAZ + Cu+2 – ''Paracoccus pantotrophus''<br /> | [[1adw]], [[3erx]], [[4bwt]] – PpPAZ + Cu+2 – ''Paracoccus pantotrophus''<br /> | ||
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[[1pmy]] – PAZ + Cu+2 – ''Methylobacterium extorquens''<br /> | [[1pmy]] – PAZ + Cu+2 – ''Methylobacterium extorquens''<br /> | ||
[[3tu6]] – PAZ + Cu+2 – ''Sinorhizobium meliloti''<br /> | [[3tu6]] – PAZ + Cu+2 – ''Sinorhizobium meliloti''<br /> | ||
| + | [[5b1j]] - PAZ + copper-containing nitrite reductase + Cu+2 - ''Hyphomicrobium denitrificans''<br /> | ||
== References == | == References == | ||
Current revision
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3D structures of pseudoazurin
Updated on 17-October-2024
1pzc – AfPAZ – Alcaligenes faecalis
1paz, 1pza, 1pzb, 3paz, 5x31 – AfPAZ + Cu+2
3nyk – AfPAZ + Co+2
4paz, 5paz, 6paz, 7paz, 8paz – AfPAZ (mutant) + Cu+2
4rh4 - AfPAZ + Zn+2
4rh4 – AfPAZ (mutant) + Zn+2
1py0 – AfPAZ (mutant) + Zn+2 + Y+2
2p80 – AfPAZ + Cu+2 + Cu-containing nitrite reductase - NMR
1zia, 1zib, 1bqk, 1bqr, 2ux6, 2ux7, 2uxf, 2uxg, 4yl4 – AcPAZ + Cu+2 – Achromobacter cycloclastes
2jkw, 8wqz, 5xmo, 5y23, 5ysg, 5yw3, 5z0x, 5ztd, 6akn, 6ifp – AcPAZ (mutant) + Cu+2
3ef4 – PAZ + Cu+2 – Hyphomicrobium denitrificans
1adw, 3erx, 4bwt – PpPAZ + Cu+2 – Paracoccus pantotrophus
4bwu, 4bxv – PpPAZ (mutant) + Cu+2
1pmy – PAZ + Cu+2 – Methylobacterium extorquens
3tu6 – PAZ + Cu+2 – Sinorhizobium meliloti
5b1j - PAZ + copper-containing nitrite reductase + Cu+2 - Hyphomicrobium denitrificans
References
- ↑ Gessmann R, Kyvelidou C, Papadovasilaki M, Petratos K. The crystal structure of cobalt-substituted pseudoazurin from Alcaligenes faecalis. Biopolymers. 2010 Oct 13. PMID:20945335 doi:10.1002/bip.21553
- ↑ Vakoufari E, Wilson KS, Petratos K. The crystal structures of reduced pseudoazurin from Alcaligenes faecalis S-6 at two pH values. FEBS Lett. 1994 Jun 27;347(2-3):203-6. PMID:8034003
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