4tsp

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==Crystal structure of FraC with DHPC bound (crystal form II)==
==Crystal structure of FraC with DHPC bound (crystal form II)==
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<StructureSection load='4tsp' size='340' side='right' caption='[[4tsp]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4tsp' size='340' side='right'caption='[[4tsp]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tsp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TSP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tsp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TSP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXG:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vwi|3vwi]], [[3wp9|3wp9]], [[4tsl|4tsl]], [[4tsn|4tsn]], [[4tso|4tso]], [[4tsq|4tsq]], [[4tsy|4tsy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXG:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>HXG</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsp OCA], [http://pdbe.org/4tsp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tsp RCSB], [http://www.ebi.ac.uk/pdbsum/4tsp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsp OCA], [https://pdbe.org/4tsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tsp RCSB], [https://www.ebi.ac.uk/pdbsum/4tsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
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[https://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4tsp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4tsp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caaveiro, J M.M]]
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[[Category: Actinia fragacea]]
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[[Category: Tanaka, K]]
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[[Category: Large Structures]]
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[[Category: Tsumoto, K]]
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[[Category: Caaveiro JMM]]
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[[Category: Actinoporin pore-forming toxin]]
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[[Category: Tanaka K]]
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[[Category: Lipid-protein interaction]]
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[[Category: Tsumoto K]]
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[[Category: Lipids phosphocholine]]
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[[Category: Membrane]]
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[[Category: Toxin]]
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Current revision

Crystal structure of FraC with DHPC bound (crystal form II)

PDB ID 4tsp

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