4tsn

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==Crystal structure of FraC with POC bound (crystal form II)==
==Crystal structure of FraC with POC bound (crystal form II)==
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<StructureSection load='4tsn' size='340' side='right' caption='[[4tsn]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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<StructureSection load='4tsn' size='340' side='right'caption='[[4tsn]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tsn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TSN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TSN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vwi|3vwi]], [[3w9p|3w9p]], [[4tsl|4tsl]], [[4tso|4tso]], [[4tsp|4tsp]], [[4tsq|4tsq]], [[4tsy|4tsy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsn OCA], [http://pdbe.org/4tsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tsn RCSB], [http://www.ebi.ac.uk/pdbsum/4tsn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsn OCA], [https://pdbe.org/4tsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tsn RCSB], [https://www.ebi.ac.uk/pdbsum/4tsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
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[https://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4tsn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4tsn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caaveiro, J M.M]]
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[[Category: Actinia fragacea]]
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[[Category: Tanaka, K]]
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[[Category: Large Structures]]
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[[Category: Tsumoto, K]]
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[[Category: Caaveiro JMM]]
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[[Category: Actinoporin]]
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[[Category: Tanaka K]]
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[[Category: Lipid-protein interaction]]
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[[Category: Tsumoto K]]
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[[Category: Membrane lipid]]
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[[Category: Phosphocholine]]
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[[Category: Pore-forming toxin]]
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[[Category: Toxin]]
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Current revision

Crystal structure of FraC with POC bound (crystal form II)

PDB ID 4tsn

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