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5kc8

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==Crystal structure of the amino-terminal domain (ATD) of iGluR Delta-2 (GluD2)==
==Crystal structure of the amino-terminal domain (ATD) of iGluR Delta-2 (GluD2)==
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<StructureSection load='5kc8' size='340' side='right' caption='[[5kc8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='5kc8' size='340' side='right'caption='[[5kc8]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kc8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KC8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KC8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.751&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kc8 OCA], [http://pdbe.org/5kc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kc8 RCSB], [http://www.ebi.ac.uk/pdbsum/5kc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kc8 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kc8 OCA], [https://pdbe.org/5kc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kc8 RCSB], [https://www.ebi.ac.uk/pdbsum/5kc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kc8 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/GRID2_HUMAN GRID2_HUMAN]] Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/GRID2_HUMAN GRID2_HUMAN] Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRID2_HUMAN GRID2_HUMAN]] Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
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[https://www.uniprot.org/uniprot/GRID2_HUMAN GRID2_HUMAN] Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5kc8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kc8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aricescu, A R]]
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[[Category: Homo sapiens]]
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[[Category: Clay, J E]]
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[[Category: Large Structures]]
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[[Category: Elegheert, J]]
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[[Category: Aricescu AR]]
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[[Category: Siebold, C]]
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[[Category: Clay JE]]
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[[Category: Neurotransmission]]
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[[Category: Elegheert J]]
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[[Category: Signaling protein]]
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[[Category: Siebold C]]

Current revision

Crystal structure of the amino-terminal domain (ATD) of iGluR Delta-2 (GluD2)

PDB ID 5kc8

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