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5fib

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==Open form of murine Acid Sphingomyelinase==
==Open form of murine Acid Sphingomyelinase==
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<StructureSection load='5fib' size='340' side='right' caption='[[5fib]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5fib' size='340' side='right'caption='[[5fib]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fib]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FIB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fi9|5fi9]], [[5fic|5fic]], [[5hqn|5hqn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphingomyelin_phosphodiesterase Sphingomyelin phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.12 3.1.4.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fib OCA], [https://pdbe.org/5fib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fib RCSB], [https://www.ebi.ac.uk/pdbsum/5fib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fib ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fib OCA], [http://pdbe.org/5fib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fib RCSB], [http://www.ebi.ac.uk/pdbsum/5fib PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fib ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ASM_MOUSE ASM_MOUSE]] Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.[UniProtKB:P17405]
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[https://www.uniprot.org/uniprot/ASM_MOUSE ASM_MOUSE] Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.[UniProtKB:P17405]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fib" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fib" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sphingomyelinase|Sphingomyelinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sphingomyelin phosphodiesterase]]
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[[Category: Large Structures]]
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[[Category: Gorelik, A]]
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[[Category: Mus musculus]]
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[[Category: Heinz, L X]]
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[[Category: Gorelik A]]
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[[Category: Illes, K]]
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[[Category: Heinz LX]]
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[[Category: Nagar, B]]
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[[Category: Illes K]]
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[[Category: Superti-Furga, G]]
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[[Category: Nagar B]]
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[[Category: Asm]]
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[[Category: Superti-Furga G]]
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[[Category: Asmase]]
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[[Category: Hydrolase]]
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[[Category: Smpd1]]
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[[Category: Sphingomyelinase]]
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Current revision

Open form of murine Acid Sphingomyelinase

PDB ID 5fib

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