5gns
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structures of human Mitofusin 1 provide insight into mitochondrial tethering== | |
| - | + | <StructureSection load='5gns' size='340' side='right'caption='[[5gns]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5gns]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.702Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gns OCA], [https://pdbe.org/5gns PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gns RCSB], [https://www.ebi.ac.uk/pdbsum/5gns PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gns ProSAT]</span></td></tr> |
| - | [[Category: Yan | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Guo X]] | ||
| + | [[Category: Hu J]] | ||
| + | [[Category: Hu X]] | ||
| + | [[Category: Huang X]] | ||
| + | [[Category: Lou Z]] | ||
| + | [[Category: Qi Y]] | ||
| + | [[Category: Rao Z]] | ||
| + | [[Category: Yan L]] | ||
| + | [[Category: Yu C]] | ||
| + | [[Category: Zhou X]] | ||
Current revision
Structures of human Mitofusin 1 provide insight into mitochondrial tethering
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Categories: Homo sapiens | Large Structures | Guo X | Hu J | Hu X | Huang X | Lou Z | Qi Y | Rao Z | Yan L | Yu C | Zhou X
