5jw4

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{{Large structure}}
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==Structure of MEDI8852 Fab Fragment in Complex with H5 HA==
==Structure of MEDI8852 Fab Fragment in Complex with H5 HA==
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<StructureSection load='5jw4' size='340' side='right' caption='[[5jw4]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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<StructureSection load='5jw4' size='340' side='right'caption='[[5jw4]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jw4]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/vietnam/1194/2004(h5n1)) Influenza a virus (a/vietnam/1194/2004(h5n1))] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(strain_a/chicken/hong_kong/yu22/2002_h5n1_genotype_z) Influenza a virus (strain a/chicken/hong kong/yu22/2002 h5n1 genotype z)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jw4]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Vietnam/1194/2004(H5N1)) Influenza A virus (A/Vietnam/1194/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JW4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw4 OCA], [http://pdbe.org/5jw4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw4 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw4 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw4 OCA], [https://pdbe.org/5jw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jw4 RCSB], [https://www.ebi.ac.uk/pdbsum/5jw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw4 ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] [[http://www.uniprot.org/uniprot/HEMA_I02A6 HEMA_I02A6]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
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[https://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jw4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jw4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Collins, P J]]
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[[Category: Homo sapiens]]
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[[Category: Gamblin, S J]]
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[[Category: Large Structures]]
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[[Category: Martin, S R]]
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[[Category: Collins PJ]]
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[[Category: Neu, U]]
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[[Category: Gamblin SJ]]
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[[Category: Ogrodowicz, R W]]
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[[Category: Martin SR]]
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[[Category: Skehel, J J]]
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[[Category: Neu U]]
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[[Category: Vorlaender, M K]]
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[[Category: Ogrodowicz RW]]
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[[Category: Walker, P A]]
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[[Category: Skehel JJ]]
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[[Category: Antibody influenza broadly neutralizing]]
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[[Category: Vorlaender MK]]
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[[Category: Immune system]]
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[[Category: Walker PA]]

Current revision

Structure of MEDI8852 Fab Fragment in Complex with H5 HA

PDB ID 5jw4

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