1kgi

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[[Image:1kgi.gif|left|200px]]
 
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{{Structure
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==Rat transthyretin (also called prealbumin) complex with 3,3',5,5'-tetraiodothyroacetic acid (t4ac)==
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|PDB= 1kgi |SIZE=350|CAPTION= <scene name='initialview01'>1kgi</scene>, resolution 1.80&Aring;
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<StructureSection load='1kgi' size='340' side='right'caption='[[1kgi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=T4A:3,3&#39;,5,5&#39;-TETRAIODOTHYROACETIC+ACID'>T4A</scene>
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<table><tr><td colspan='2'>[[1kgi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KGI FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T4A:3,3,5,5-TETRAIODOTHYROACETIC+ACID'>T4A</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgi OCA], [https://pdbe.org/1kgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kgi RCSB], [https://www.ebi.ac.uk/pdbsum/1kgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgi ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1gke|1GKE]], [[2rox|2ROX]], [[1ked|1KED]], [[1kgj|1KGJ]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgi OCA], [http://www.ebi.ac.uk/pdbsum/1kgi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kgi RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kgi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of rat transthyretin (rTTR) complex with 3,5,3',5'-tetraiodothyroacetic acid (T4Ac) was determined at 1.8 A resolution with low temperature synchrotron data collected at CHESS. The structure was refined to R = 0.207 and Rfree = 0.24 with the use of 8-1.8 A data. The additional 8000 reflections from the incomplete 2.1-1.8 data shell, included in the refinement, reduced the Rfree index by 1.3%. Structure comparison with the model refined against the complete 8-2.1 A data revealed no differences in the ligand orientation and the conformation of the polypeptide chain in the core regions. However, the high-resolution data included in the refinement improved the model in the flexible regions poorly defined with the lower resolution data. Also additional sixteen water molecules were found in the difference map calculated with the extended data. The structure revealed both forward and reverse binding of tetraiodothyroacetic acid in one binding site and two modes of forward ligand binding in the second site, with the phenolic iodine atoms occupying different sets of the halogen binding pockets.
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'''Rat transthyretin (also called prealbumin) complex with 3,3',5,5'-tetraiodothyroacetic acid (t4ac)'''
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Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution.,Muziol T, Cody V, Luft JR, Pangborn W, Wojtczak A Acta Biochim Pol. 2001;48(4):877-84. PMID:11995998<ref>PMID:11995998</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1kgi" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The crystal structure of rat transthyretin (rTTR) complex with 3,5,3',5'-tetraiodothyroacetic acid (T4Ac) was determined at 1.8 A resolution with low temperature synchrotron data collected at CHESS. The structure was refined to R = 0.207 and Rfree = 0.24 with the use of 8-1.8 A data. The additional 8000 reflections from the incomplete 2.1-1.8 data shell, included in the refinement, reduced the Rfree index by 1.3%. Structure comparison with the model refined against the complete 8-2.1 A data revealed no differences in the ligand orientation and the conformation of the polypeptide chain in the core regions. However, the high-resolution data included in the refinement improved the model in the flexible regions poorly defined with the lower resolution data. Also additional sixteen water molecules were found in the difference map calculated with the extended data. The structure revealed both forward and reverse binding of tetraiodothyroacetic acid in one binding site and two modes of forward ligand binding in the second site, with the phenolic iodine atoms occupying different sets of the halogen binding pockets.
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*[[Transthyretin 3D structures|Transthyretin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1KGI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGI OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution., Muziol T, Cody V, Luft JR, Pangborn W, Wojtczak A, Acta Biochim Pol. 2001;48(4):877-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11995998 11995998]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Cody V]]
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[[Category: Cody, V.]]
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[[Category: Luft JR]]
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[[Category: Luft, J R.]]
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[[Category: Muziol T]]
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[[Category: Muziol, T.]]
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[[Category: Neumann P]]
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[[Category: Neumann, P.]]
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[[Category: Pangborn W]]
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[[Category: Pangborn, W.]]
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[[Category: Wojtczak A]]
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[[Category: Wojtczak, A.]]
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[[Category: prealbumin]]
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[[Category: tetraiodothyroacetic acid]]
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[[Category: thyroid ho]]
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[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:20 2008''
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Current revision

Rat transthyretin (also called prealbumin) complex with 3,3',5,5'-tetraiodothyroacetic acid (t4ac)

PDB ID 1kgi

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