3f5c

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==Structure of Dax-1:LRH-1 complex==
==Structure of Dax-1:LRH-1 complex==
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<StructureSection load='3f5c' size='340' side='right' caption='[[3f5c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='3f5c' size='340' side='right'caption='[[3f5c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5C FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr5a2, Lrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Nr0b1, Ahch, Dax1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [http://pdbe.org/3f5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [http://www.ebi.ac.uk/pdbsum/3f5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5c ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [https://pdbe.org/3f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [https://www.ebi.ac.uk/pdbsum/3f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR5A2_MOUSE NR5A2_MOUSE]] Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity). [[http://www.uniprot.org/uniprot/NR0B1_MOUSE NR0B1_MOUSE]] Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).<ref>PMID:16466956</ref>
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[https://www.uniprot.org/uniprot/NR5A2_MOUSE NR5A2_MOUSE] Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3f5c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3f5c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Liver receptor homolog-1|Liver receptor homolog-1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Fletterick, R J]]
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[[Category: Mus musculus]]
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[[Category: Sablin, E P]]
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[[Category: Fletterick RJ]]
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[[Category: Dna-binding]]
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[[Category: Sablin EP]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Receptor]]
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[[Category: Regulatory complex]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcriptional corepressor]]
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[[Category: Zinc-finger]]
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Current revision

Structure of Dax-1:LRH-1 complex

PDB ID 3f5c

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