This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4caf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:10, 9 May 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 34a)==
==Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 34a)==
-
<StructureSection load='4caf' size='340' side='right' caption='[[4caf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+
<StructureSection load='4caf' size='340' side='right'caption='[[4caf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4caf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavi Plavi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAF FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4caf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAF FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=370:4-[(2-{5-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)METHYL]-1,3,4-OXADIAZOL-2-YL}-1-BENZOTHIOPHEN-3-YL)OXY]PIPERIDINE'>370</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cae|4cae]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=370:4-[(2-{5-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)METHYL]-1,3,4-OXADIAZOL-2-YL}-1-BENZOTHIOPHEN-3-YL)OXY]PIPERIDINE'>370</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4caf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caf OCA], [https://pdbe.org/4caf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4caf RCSB], [https://www.ebi.ac.uk/pdbsum/4caf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4caf ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caf OCA], [http://pdbe.org/4caf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4caf RCSB], [http://www.ebi.ac.uk/pdbsum/4caf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4caf ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
+
[https://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
+
[[Category: Large Structures]]
-
[[Category: Plavi]]
+
[[Category: Plasmodium vivax]]
-
[[Category: Brannigan, J A]]
+
[[Category: Brannigan JA]]
-
[[Category: Holder, A A]]
+
[[Category: Holder AA]]
-
[[Category: Leatherbarrow, R J]]
+
[[Category: Leatherbarrow RJ]]
-
[[Category: Rackham, M D]]
+
[[Category: Rackham MD]]
-
[[Category: Rangachari, K]]
+
[[Category: Rangachari K]]
-
[[Category: Tate, E W]]
+
[[Category: Tate EW]]
-
[[Category: Wilkinson, A J]]
+
[[Category: Wilkinson AJ]]
-
[[Category: Benzothiophene]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Malaria]]
+
-
[[Category: Myristoylation]]
+
-
[[Category: Transferase]]
+

Current revision

Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 34a)

PDB ID 4caf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4caf"
Personal tools