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4bu1

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==Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide==
==Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide==
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<StructureSection load='4bu1' size='340' side='right' caption='[[4bu1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4bu1' size='340' side='right'caption='[[4bu1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bu1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BU1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bu1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BU1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bu0|4bu0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bu1 OCA], [https://pdbe.org/4bu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bu1 RCSB], [https://www.ebi.ac.uk/pdbsum/4bu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bu1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bu1 OCA], [http://pdbe.org/4bu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bu1 RCSB], [http://www.ebi.ac.uk/pdbsum/4bu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bu1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAD4_SCHPO RAD4_SCHPO]] Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. [[http://www.uniprot.org/uniprot/RHP9_SCHPO RHP9_SCHPO]] Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage.<ref>PMID:9153313</ref> <ref>PMID:9407031</ref> <ref>PMID:15550243</ref>
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[https://www.uniprot.org/uniprot/RAD4_SCHPO RAD4_SCHPO] Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4bu1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4bu1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA repair protein Rad4|DNA repair protein Rad4]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 356]]
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[[Category: Large Structures]]
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[[Category: Carr, A M]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Du, L L]]
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[[Category: Carr AM]]
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[[Category: Garcia, V]]
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[[Category: Du LL]]
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[[Category: Oliver, A W]]
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[[Category: Garcia V]]
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[[Category: Pearl, L H]]
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[[Category: Oliver AW]]
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[[Category: Qu, M]]
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[[Category: Pearl LH]]
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[[Category: Rappas, M]]
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[[Category: Qu M]]
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[[Category: Wardlaw, C P]]
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[[Category: Rappas M]]
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[[Category: Dna damage checkpoint]]
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[[Category: Wardlaw CP]]
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[[Category: Replication]]
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[[Category: Topbp1]]
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Current revision

Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide

PDB ID 4bu1

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