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3prx
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==Structure of Complement C5 in Complex with CVF and SSL7== | ==Structure of Complement C5 in Complex with CVF and SSL7== | ||
| - | <StructureSection load='3prx' size='340' side='right' caption='[[3prx]], [[Resolution|resolution]] 4.30Å' scene=''> | + | <StructureSection load='3prx' size='340' side='right'caption='[[3prx]], [[Resolution|resolution]] 4.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3prx]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3prx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prx OCA], [https://pdbe.org/3prx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3prx RCSB], [https://www.ebi.ac.uk/pdbsum/3prx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3prx ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | {{Large structure}} | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[https://omim.org/entry/609536 609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Cobra venom factor|Cobra venom factor]] | *[[Cobra venom factor|Cobra venom factor]] | ||
| - | *[[Complement C5|Complement C5]] | + | *[[Complement C5 3D structures|Complement C5 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Naja kaouthia]] | [[Category: Naja kaouthia]] | ||
| - | [[Category: Andersen, G R]] | ||
| - | [[Category: Andersen, K R]] | ||
| - | [[Category: Braren, I]] | ||
| - | [[Category: Laursen, N S]] | ||
| - | [[Category: Sottrup-Jensen, L]] | ||
| - | [[Category: Spillner, E]] | ||
| - | [[Category: Complement]] | ||
| - | [[Category: Immune system]] | ||
| - | [[Category: Immune system-toxin complex]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Andersen GR]] | ||
| + | [[Category: Andersen KR]] | ||
| + | [[Category: Braren I]] | ||
| + | [[Category: Laursen NS]] | ||
| + | [[Category: Sottrup-Jensen L]] | ||
| + | [[Category: Spillner E]] | ||
Current revision
Structure of Complement C5 in Complex with CVF and SSL7
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