4gzk

<StructureSection load='4gzk' size='340' side='right' caption='[[4gzk]], [[Resolution|resolution]] 1.69&Aring;' scene=''>

<table><tr><td colspan='2'>[[4gzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_phi-12 Bacteriophage phi-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=161736 Bacteriophage phi-12])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzk OCA], [http://pdbe.org/4gzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gzk RCSB], [http://www.ebi.ac.uk/pdbsum/4gzk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gzk ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

We have determined the structure of P2, the self-priming RdRp from cystovirus varphi12 in two crystal forms (A, B) at resolutions of 1.7 A and 2.1 A. Form A contains Mg(2+) bound at a site that deviates from the canonical noncatalytic position seen in form B. These structures provide insight into the temperature sensitivity of a ts-mutant. However, the tunnel through which template ssRNA accesses the active site is partially occluded by a flexible loop; this feature, along with suboptimal positioning of other structural elements that prevent the formation of a stable initiation complex, indicate an inactive conformation in crystallo. Proteins 2013; 81:1479-1484. (c) 2013 Wiley Periodicals, Inc.

 

Structure of the RNA-directed RNA Polymerase from the cystovirus varphi12.,Ren Z, C Franklin M, Ghose R Proteins. 2013 Aug;81(8):1479-84. doi: 10.1002/prot.24297. Epub 2013 Jun 1. PMID:23568335<ref>PMID:23568335</ref>

 

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4gzk" style="background-color:#fffaf0;"></div>

*[[RNA polymerase|RNA polymerase]]

[[Category: Bacteriophage phi-12]]

[[Category: Franklin, M]]

[[Category: Ghose, R]]

[[Category: Ren, Z]]

[[Category: Rna-directed rna polymerase]]

[[Category: Transferase]]