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4igb

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==Crystal structure of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707==
==Crystal structure of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707==
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<StructureSection load='4igb' size='340' side='right' caption='[[4igb]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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<StructureSection load='4igb' size='340' side='right'caption='[[4igb]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4igb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strgc Strgc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IGB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4igb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_gordonii_str._Challis Streptococcus gordonii str. Challis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IGB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SGO_0707 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29390 STRGC])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igb OCA], [http://pdbe.org/4igb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4igb RCSB], [http://www.ebi.ac.uk/pdbsum/4igb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4igb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igb OCA], [https://pdbe.org/4igb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4igb RCSB], [https://www.ebi.ac.uk/pdbsum/4igb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4igb ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A8AW49_STRGC A8AW49_STRGC]
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The commensal Streptococcus gordonii expresses numerous surface adhesins with which it interacts with other microorganisms, host cells and salivary proteins to initiate dental plaque formation. However, this Gram-positive bacterium can also spread to non-oral sites such as the heart valves and cause infective endocarditis. One of its surface adhesins, Sgo0707, is a large protein composed of a non-repetitive N-terminal region followed by several C-terminal repeat domains and a cell wall sorting motif. Here we present the crystal structure of the Sgo0707 N-terminal domains, refined to 2.1 A resolution. The model consists of two domains, N1 and N2. The largest domain, N1, comprises a putative binding cleft with a single cysteine located in its centre and exhibits an unexpected structural similarity to the variable domains of the streptococcal Antigen I/II adhesins. The N2-domain has an IgG-like fold commonly found among Gram-positive surface adhesins. Binding studies performed on S. gordonii wild-type and a Sgo0707 deficient mutant show that the Sgo0707 adhesin is involved in binding to type-1 collagen and to oral keratinocytes.
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Structural and Functional Analysis of the N-terminal Domain of the Streptococcus gordonii Adhesin Sgo0707.,Nylander A, Svensater G, Senadheera DB, Cvitkovitch DG, Davies JR, Persson K PLoS One. 2013 May 17;8(5):e63768. doi: 10.1371/journal.pone.0063768. Print 2013. PMID:23691093<ref>PMID:23691093</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4igb" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Strgc]]
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[[Category: Large Structures]]
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[[Category: Cvitkovitch, D G]]
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[[Category: Streptococcus gordonii str. Challis]]
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[[Category: Davies, J R]]
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[[Category: Cvitkovitch DG]]
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[[Category: Nylander, A]]
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[[Category: Davies JR]]
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[[Category: Persson, K]]
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[[Category: Nylander A]]
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[[Category: Senadheera, D B]]
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[[Category: Persson K]]
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[[Category: Svensater, G]]
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[[Category: Senadheera DB]]
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[[Category: Adhesin]]
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[[Category: Svensater G]]
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[[Category: Beta-sandwich fold]]
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[[Category: Cell adhesion]]
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[[Category: Cell wall anchored protein]]
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[[Category: Collagen-binding]]
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[[Category: Oral keratinocyte]]
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Current revision

Crystal structure of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707

PDB ID 4igb

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