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3lit

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==The crystal structure of htlv protease complexed with the inhibitor KNI-10681==
==The crystal structure of htlv protease complexed with the inhibitor KNI-10681==
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<StructureSection load='3lit' size='340' side='right' caption='[[3lit]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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<StructureSection load='3lit' size='340' side='right'caption='[[3lit]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lit]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-1 Htlv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LIT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lit]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LIT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E15:(4R)-3-[(2S,3S)-3-[[(2S)-2-[[(2S)-2-AZANYL-2-PHENYL-ETHANOYL]AMINO]-3,3-DIMETHYL-BUTANOYL]AMINO]-2-HYDROXY-4-PHENYL-BUTANOYL]-5,5-DIMETHYL-N-[(2R)-3-METHYLBUTAN-2-YL]-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>E15</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b7f|2b7f]], [[3liq|3liq]], [[3lin|3lin]], [[3liv|3liv]], [[3lix|3lix]], [[3liy|3liy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E15:(4R)-3-[(2S,3S)-3-[[(2S)-2-[[(2S)-2-AZANYL-2-PHENYL-ETHANOYL]AMINO]-3,3-DIMETHYL-BUTANOYL]AMINO]-2-HYDROXY-4-PHENYL-BUTANOYL]-5,5-DIMETHYL-N-[(2R)-3-METHYLBUTAN-2-YL]-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>E15</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11908 HTLV-1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lit OCA], [https://pdbe.org/3lit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lit RCSB], [https://www.ebi.ac.uk/pdbsum/3lit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lit ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lit OCA], [http://pdbe.org/3lit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lit RCSB], [http://www.ebi.ac.uk/pdbsum/3lit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lit ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q82134_9DELA Q82134_9DELA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/3lit_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/3lit_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3lit" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3lit" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Htlv-1]]
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[[Category: Human T-cell leukemia virus type I]]
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[[Category: Gustchina, A]]
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[[Category: Large Structures]]
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[[Category: Kiso, Y]]
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[[Category: Gustchina A]]
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[[Category: Li, M]]
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[[Category: Kiso Y]]
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[[Category: Nguyen, J]]
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[[Category: Li M]]
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[[Category: Satoh, T]]
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[[Category: Nguyen J]]
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[[Category: Wlodawer, A]]
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[[Category: Satoh T]]
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[[Category: Hydrolase]]
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[[Category: Wlodawer A]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

The crystal structure of htlv protease complexed with the inhibitor KNI-10681

PDB ID 3lit

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OCA

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