3vpp

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==Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain==
==Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain==
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<StructureSection load='3vpp' size='340' side='right' caption='[[3vpp]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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<StructureSection load='3vpp' size='340' side='right'caption='[[3vpp]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VPP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VPP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.642&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLEC9A, UNQ9341/PRO34046 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vpp OCA], [http://pdbe.org/3vpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vpp RCSB], [http://www.ebi.ac.uk/pdbsum/3vpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vpp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vpp OCA], [https://pdbe.org/3vpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vpp RCSB], [https://www.ebi.ac.uk/pdbsum/3vpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vpp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLC9A_HUMAN CLC9A_HUMAN]] Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.<ref>PMID:18497879</ref> <ref>PMID:22483802</ref>
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[https://www.uniprot.org/uniprot/CLC9A_HUMAN CLC9A_HUMAN] Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.<ref>PMID:18497879</ref> <ref>PMID:22483802</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Colman, P M]]
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[[Category: Large Structures]]
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[[Category: Czabotar, P E]]
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[[Category: Colman PM]]
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[[Category: Lahoud, M H]]
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[[Category: Czabotar PE]]
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[[Category: Policheni, A N]]
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[[Category: Lahoud MH]]
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[[Category: Shortman, K]]
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[[Category: Policheni AN]]
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[[Category: Zhang, J G]]
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[[Category: Shortman K]]
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[[Category: C-type lectin-like domain]]
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[[Category: Zhang JG]]
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[[Category: Dendritic cell]]
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[[Category: Immune system]]
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[[Category: Membrane]]
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Current revision

Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain

PDB ID 3vpp

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