3lzd

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==Crystal structure of Dph2 from Pyrococcus horikoshii with 4Fe-4S cluster==
==Crystal structure of Dph2 from Pyrococcus horikoshii with 4Fe-4S cluster==
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<StructureSection load='3lzd' size='340' side='right' caption='[[3lzd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3lzd' size='340' side='right'caption='[[3lzd]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lzd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LZD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LZD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lzc|3lzc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lzd OCA], [http://pdbe.org/3lzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lzd RCSB], [http://www.ebi.ac.uk/pdbsum/3lzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lzd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lzd OCA], [https://pdbe.org/3lzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lzd RCSB], [https://www.ebi.ac.uk/pdbsum/3lzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lzd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPH2_PYRHO DPH2_PYRHO]] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).<ref>PMID:20559380</ref>
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[https://www.uniprot.org/uniprot/DPH2_PYRHO DPH2_PYRHO] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).<ref>PMID:20559380</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/3lzd_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lz/3lzd_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyrococcus shinkaii]]
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[[Category: Large Structures]]
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[[Category: Dzikovski, B]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Ealick, S E]]
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[[Category: Dzikovski B]]
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[[Category: Freed, J]]
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[[Category: Ealick SE]]
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[[Category: Koralewski, R M]]
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[[Category: Freed J]]
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[[Category: Krebs, C]]
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[[Category: Koralewski RM]]
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[[Category: Lee, M]]
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[[Category: Krebs C]]
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[[Category: Lin, H]]
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[[Category: Lee M]]
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[[Category: Torelli, A T]]
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[[Category: Lin H]]
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[[Category: Wang, E]]
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[[Category: Torelli AT]]
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[[Category: Zhang, Y]]
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[[Category: Wang E]]
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[[Category: Zhu, X]]
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[[Category: Zhang Y]]
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[[Category: Biosynthetic protein]]
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[[Category: Zhu X]]
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[[Category: Diphthamide biosynthesis]]
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[[Category: Gene triplication]]
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[[Category: Iron-sulfur cluster]]
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[[Category: Radical sam enzyme]]
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Current revision

Crystal structure of Dph2 from Pyrococcus horikoshii with 4Fe-4S cluster

PDB ID 3lzd

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OCA

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