4b8l

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==Aurora B kinase P353G mutant==
==Aurora B kinase P353G mutant==
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<StructureSection load='4b8l' size='340' side='right' caption='[[4b8l]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4b8l' size='340' side='right'caption='[[4b8l]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b8l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b8l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A0P:9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]OXY}PHOSPHORYL]-ALPHA-L-ARABINOFURANOSYL}-9H-PURIN-6-AMINE'>A0P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bfx|2bfx]], [[2bfy|2bfy]], [[2vgo|2vgo]], [[2vgp|2vgp]], [[2vrx|2vrx]], [[3ztx|3ztx]], [[4b8m|4b8m]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A0P:9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]OXY}PHOSPHORYL]-ALPHA-L-ARABINOFURANOSYL}-9H-PURIN-6-AMINE'>A0P</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8l OCA], [https://pdbe.org/4b8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8l RCSB], [https://www.ebi.ac.uk/pdbsum/4b8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8l OCA], [http://pdbe.org/4b8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b8l RCSB], [http://www.ebi.ac.uk/pdbsum/4b8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8l ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AUKBA_XENLA AUKBA_XENLA]] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Phosphorylates 'Ser-10' of histone H3 during mitosis.<ref>PMID:12221116</ref> <ref>PMID:11350965</ref> <ref>PMID:17199039</ref> [[http://www.uniprot.org/uniprot/INCEA_XENLA INCEA_XENLA]] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with aurkb or aurkc. Seems to bind directly to microtubules.<ref>PMID:12221116</ref> <ref>PMID:17199039</ref>
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[https://www.uniprot.org/uniprot/INCEA_XENLA INCEA_XENLA] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with aurkb or aurkc. Seems to bind directly to microtubules.<ref>PMID:12221116</ref> <ref>PMID:17199039</ref>
==See Also==
==See Also==
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*[[Centromere protein|Centromere protein]]
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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*[[Inner centromere protein|Inner centromere protein]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African clawed frog]]
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[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Xenopus laevis]]
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[[Category: Sessa, F]]
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[[Category: Sessa F]]
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[[Category: Villa, F]]
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[[Category: Villa F]]
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[[Category: Cancer]]
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[[Category: Cell cycle]]
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Current revision

Aurora B kinase P353G mutant

PDB ID 4b8l

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