3lwk

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==Crystal structure of human Beta-crystallin A4 (CRYBA4)==
==Crystal structure of human Beta-crystallin A4 (CRYBA4)==
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<StructureSection load='3lwk' size='340' side='right' caption='[[3lwk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3lwk' size='340' side='right'caption='[[3lwk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lwk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LWK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lwk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRYBA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwk OCA], [http://pdbe.org/3lwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lwk RCSB], [http://www.ebi.ac.uk/pdbsum/3lwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwk OCA], [https://pdbe.org/3lwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwk RCSB], [https://www.ebi.ac.uk/pdbsum/3lwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwk ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CRBA4_HUMAN CRBA4_HUMAN]] Defects in CRYBA4 are the cause of cataract zonular type 2 (CZ2) [MIM:[http://omim.org/entry/610425 610425]]; also known as lamellar cataract 2. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.<ref>PMID:16960806</ref> Defects in CRYBA4 are a cause of microphthalmia isolated with cataract type 4 (MCOPCT4) [MIM:[http://omim.org/entry/610426 610426]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.<ref>PMID:16960806</ref>
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[https://www.uniprot.org/uniprot/CRBA4_HUMAN CRBA4_HUMAN] Defects in CRYBA4 are the cause of cataract zonular type 2 (CZ2) [MIM:[https://omim.org/entry/610425 610425]; also known as lamellar cataract 2. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.<ref>PMID:16960806</ref> Defects in CRYBA4 are a cause of microphthalmia isolated with cataract type 4 (MCOPCT4) [MIM:[https://omim.org/entry/610426 610426]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.<ref>PMID:16960806</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CRBA4_HUMAN CRBA4_HUMAN]] Crystallins are the dominant structural components of the vertebrate eye lens.
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[https://www.uniprot.org/uniprot/CRBA4_HUMAN CRBA4_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwk_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lwk ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lwk ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Crystallin 3D structures|Crystallin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Chaikuad, A]]
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[[Category: Bountra C]]
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[[Category: Cocking, R]]
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[[Category: Chaikuad A]]
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[[Category: Edwards, A M]]
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[[Category: Cocking R]]
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[[Category: Krojer, T]]
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[[Category: Edwards AM]]
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[[Category: Muniz, J R.C]]
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[[Category: Krojer T]]
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[[Category: Oppermann, U]]
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[[Category: Muniz JRC]]
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[[Category: Pike, A C.W]]
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[[Category: Oppermann U]]
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[[Category: Structural genomic]]
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[[Category: Pike ACW]]
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[[Category: Shafqat, N]]
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[[Category: Shafqat N]]
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[[Category: Vollmar, M]]
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[[Category: Vollmar M]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Yue, W W]]
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[[Category: Yue WW]]
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[[Category: Beta-crystallin]]
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[[Category: Cataract]]
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[[Category: Disease mutation]]
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[[Category: Eye lens protein]]
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[[Category: Microphthalmia]]
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[[Category: Oxidation]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of human Beta-crystallin A4 (CRYBA4)

PDB ID 3lwk

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