4ef9

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==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate==
==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate==
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<StructureSection load='4ef9' size='340' side='right' caption='[[4ef9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='4ef9' size='340' side='right'caption='[[4ef9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ef9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EF9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ef9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NF:N-(4-NITROPHENYL)THIOFORMAMIDE'>4NF</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ef8|4ef8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4NF:N-(4-NITROPHENYL)THIOFORMAMIDE'>4NF</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHODH, lmjf16.0530, LMJF_16_0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef9 OCA], [https://pdbe.org/4ef9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ef9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef9 OCA], [http://pdbe.org/4ef9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ef9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ef9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef9 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4QEW7_LEIMA Q4QEW7_LEIMA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leima]]
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[[Category: Large Structures]]
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[[Category: Emery, F S]]
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[[Category: Nonato, M C]]
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[[Category: Pinheiro, M P]]
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[[Category: 4-nitrophenyl isothiocyanate]]
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[[Category: Dihydroorotate dehydrogenase]]
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[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: Oxidoreductase]]
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[[Category: Emery FS]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Nonato MC]]
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[[Category: Pyrd]]
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[[Category: Pinheiro MP]]

Current revision

Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate

PDB ID 4ef9

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