3tyy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:43, 14 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of Human Lamin-B1 Coil 2 Segment==
==Crystal Structure of Human Lamin-B1 Coil 2 Segment==
-
<StructureSection load='3tyy' size='340' side='right' caption='[[3tyy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+
<StructureSection load='3tyy' size='340' side='right'caption='[[3tyy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3tyy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mov 3mov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TYY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3tyy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mov 3mov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TYY FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LMN2, LMNB, LMNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.399&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tyy OCA], [http://pdbe.org/3tyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tyy RCSB], [http://www.ebi.ac.uk/pdbsum/3tyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tyy ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tyy OCA], [https://pdbe.org/3tyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tyy RCSB], [https://www.ebi.ac.uk/pdbsum/3tyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tyy ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN]] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[http://omim.org/entry/169500 169500]]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref>
+
[https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[https://omim.org/entry/169500 169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN]] Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
+
[https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
We present here the crystal structures of human lamin B1 globular tail domain and coiled 2B domain, which adopt similar folds to Ig-like domain and coiled-coil domain of lamin A, respectively. Despite the overall similarity, we found an extra intermolecular disulfide bond in the lamin B1 coil 2B domain, which does not exist in lamin A/C. In addition, the structural analysis indicates that interactions at the lamin B1 homodimer interface are quite different from those of lamin A/C. Thus our research not only reveals the diversely formed homodimers among lamin family members, but also sheds light on understanding the important roles of lamin B1 in forming the nuclear lamina matrix. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: Lamin-B and Lamin-Bbind by x-ray crystallography (View interaction).
+
-
 
+
-
Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.,Ruan J, Xu C, Bian C, Lam R, Wang JP, Kania J, Min J, Zang J FEBS Lett. 2012 Feb 17;586(4):314-8. Epub 2012 Jan 16. PMID:22265972<ref>PMID:22265972</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3tyy" style="background-color:#fffaf0;"></div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Large Structures]]
-
[[Category: Bian, C B]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bochkarev, A]]
+
[[Category: Bian CB]]
-
[[Category: Bountra, C]]
+
[[Category: Bochkarev A]]
-
[[Category: Edwards, A M]]
+
[[Category: Bountra C]]
-
[[Category: Lam, R]]
+
[[Category: Edwards AM]]
-
[[Category: Mackenzie, F]]
+
[[Category: Lam R]]
-
[[Category: Min, J]]
+
[[Category: Mackenzie F]]
-
[[Category: Structural genomic]]
+
[[Category: Min J]]
-
[[Category: Walker, J R]]
+
[[Category: Walker JR]]
-
[[Category: Weigelt, J]]
+
[[Category: Weigelt J]]
-
[[Category: Xu, C]]
+
[[Category: Xu C]]
-
[[Category: B-type lamin]]
+
-
[[Category: Lamin-b1]]
+
-
[[Category: Lmnb1]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural protein]]
+

Current revision

Crystal Structure of Human Lamin-B1 Coil 2 Segment

PDB ID 3tyy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3tyy"
Personal tools