3lwv

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==Structure of H/ACA RNP bound to a substrate RNA containing 2'-deoxyuridine==
==Structure of H/ACA RNP bound to a substrate RNA containing 2'-deoxyuridine==
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<StructureSection load='3lwv' size='340' side='right' caption='[[3lwv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3lwv' size='340' side='right'caption='[[3lwv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lwv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LWV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lwv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.499&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lwo|3lwo]], [[3lwp|3lwp]], [[3lwq|3lwq]], [[3lwr|3lwr]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwv OCA], [https://pdbe.org/3lwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwv RCSB], [https://www.ebi.ac.uk/pdbsum/3lwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwv OCA], [http://pdbe.org/3lwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lwv RCSB], [http://www.ebi.ac.uk/pdbsum/3lwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). [[http://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity).
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[https://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwv_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[TRNA pseudouridine synthase|TRNA pseudouridine synthase]]
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*[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]]
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*[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]]
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*[[Ribosome biogenesis protein 3D structures|Ribosome biogenesis protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43587]]
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[[Category: Large Structures]]
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[[Category: Li, H]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Liang, B]]
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[[Category: Synthetic construct]]
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[[Category: Lv, C]]
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[[Category: Li H]]
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[[Category: Yang, W]]
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[[Category: Liang B]]
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[[Category: Zhou, J]]
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[[Category: Lv C]]
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[[Category: H/aca pseudouridine synthase]]
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[[Category: Yang W]]
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[[Category: Isomerase]]
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[[Category: Zhou J]]
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[[Category: Isomerase-rna binding protein-rna complex]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome biogenesis]]
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[[Category: Rna-binding]]
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[[Category: Rrna processing]]
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[[Category: Trna processing]]
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Current revision

Structure of H/ACA RNP bound to a substrate RNA containing 2'-deoxyuridine

PDB ID 3lwv

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Proteopedia Page Contributors and Editors (what is this?)

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