1kt0

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[[Image:1kt0.gif|left|200px]]
 
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{{Structure
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==Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes==
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|PDB= 1kt0 |SIZE=350|CAPTION= <scene name='initialview01'>1kt0</scene>, resolution 2.70&Aring;
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<StructureSection load='1kt0' size='340' side='right'caption='[[1kt0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1kt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KT0 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE= FKBP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt0 OCA], [https://pdbe.org/1kt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kt0 RCSB], [https://www.ebi.ac.uk/pdbsum/1kt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kt0 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1kt1|1KT1]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kt0 OCA], [http://www.ebi.ac.uk/pdbsum/1kt0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kt0 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1kt0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kt0 ConSurf].
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<div style="clear:both"></div>
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'''Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes'''
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The ability to bind immunosuppressive drugs such as cyclosporin and FK506 defines the immunophilin family of proteins, and the FK506-binding proteins form the FKBP subfamily of immunophilins. Some FKBPs, notably FKBP12 (the 12-kDa FK506-binding protein), have defined roles in regulating ion channels or cell signaling, and well established structures. Other FKBPs, especially the larger ones, participate in important biological processes, but their exact roles and the structural bases for these roles are poorly defined. FKBP51 (the 51-kDa FKBP) associates with heat shock protein 90 (Hsp90) and appears in functionally mature steroid receptor complexes. In New World monkeys, FKBP51 has been implicated in cortisol resistance. We report here the x-ray structures of human FKBP51, to 2.7 A, and squirrel monkey FKBP51, to 2.8 A, by using multiwavelength anomalous dispersion phasing. FKBP51 is composed of three domains: two consecutive FKBP domains and a three-unit repeat of the TPR (tetratricopeptide repeat) domain. This structure of a multi-FKBP domain protein clarifies the arrangement of these domains and their possible interactions with other proteins. The two FKBP domains differ by an insertion in the second that affects the formation of the progesterone receptor complex.
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==Disease==
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Known disease associated with this structure: Major depressive disorder and accelerated response to antidepressant drug treatment OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602623 602623]]
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==About this Structure==
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1KT0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KT0 OCA].
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==Reference==
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Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes., Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J, Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):868-73. Epub 2003 Jan 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12538866 12538866]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cheung-Flynn J]]
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[[Category: Cheung-Flynn, J.]]
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[[Category: Clardy JC]]
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[[Category: Clardy, J C.]]
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[[Category: Rimerman RA]]
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[[Category: Rimerman, R A.]]
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[[Category: Scammell JG]]
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[[Category: Scammell, J G.]]
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[[Category: Sinars CR]]
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[[Category: Sinars, C R.]]
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[[Category: Smith DF]]
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[[Category: Smith, D F.]]
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[[Category: fkbp-like ppiase]]
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[[Category: tpr repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:53:10 2008''
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Current revision

Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes

PDB ID 1kt0

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