4gqg

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==Crystal structure of AKR1B10 complexed with NADP+==
==Crystal structure of AKR1B10 complexed with NADP+==
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<StructureSection load='4gqg' size='340' side='right' caption='[[4gqg]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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<StructureSection load='4gqg' size='340' side='right'caption='[[4gqg]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqg OCA], [http://pdbe.org/4gqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gqg RCSB], [http://www.ebi.ac.uk/pdbsum/4gqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqg OCA], [https://pdbe.org/4gqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqg RCSB], [https://www.ebi.ac.uk/pdbsum/4gqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4gqg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4gqg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chen, S]]
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[[Category: Large Structures]]
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[[Category: Hu, X]]
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[[Category: Chen S]]
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[[Category: Zhai, J]]
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[[Category: Hu X]]
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[[Category: Zhang, L]]
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[[Category: Zhai J]]
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[[Category: Zheng, X]]
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[[Category: Zhang L]]
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[[Category: Alpha-beta tim barrel]]
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[[Category: Zheng X]]
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[[Category: Nadp+]]
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[[Category: Nadp-dependant oxidoreductase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of AKR1B10 complexed with NADP+

PDB ID 4gqg

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