4f6p

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==Crystal structure of the yeast metacaspase Yca1 C276A mutant==
==Crystal structure of the yeast metacaspase Yca1 C276A mutant==
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<StructureSection load='4f6p' size='340' side='right' caption='[[4f6p]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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<StructureSection load='4f6p' size='340' side='right'caption='[[4f6p]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4f6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F6P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4f6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F6P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DFH:1,1-DIPHENYLETHANOL'>DFH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.619&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f6o|4f6o]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DFH:1,1-DIPHENYLETHANOL'>DFH</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCA1, YCA1, YOR197W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f6p OCA], [https://pdbe.org/4f6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f6p RCSB], [https://www.ebi.ac.uk/pdbsum/4f6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f6p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f6p OCA], [http://pdbe.org/4f6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f6p RCSB], [http://www.ebi.ac.uk/pdbsum/4f6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f6p ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MCA1_YEAST MCA1_YEAST]] Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.<ref>PMID:11983181</ref> <ref>PMID:15489197</ref> <ref>PMID:15381687</ref> <ref>PMID:14970189</ref> <ref>PMID:14718573</ref> <ref>PMID:16170310</ref> <ref>PMID:15668299</ref> <ref>PMID:15939758</ref> <ref>PMID:16079294</ref> <ref>PMID:16301538</ref> <ref>PMID:20624963</ref>
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[https://www.uniprot.org/uniprot/MCA1_YEAST MCA1_YEAST] Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth.<ref>PMID:11983181</ref> <ref>PMID:15489197</ref> <ref>PMID:15381687</ref> <ref>PMID:14970189</ref> <ref>PMID:14718573</ref> <ref>PMID:16170310</ref> <ref>PMID:15668299</ref> <ref>PMID:15939758</ref> <ref>PMID:16079294</ref> <ref>PMID:16301538</ref> <ref>PMID:20624963</ref>
==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: Shi, Y G]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Wong, A H]]
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[[Category: Shi YG]]
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[[Category: Yan, C Y]]
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[[Category: Wong AH]]
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[[Category: Hydrolase]]
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[[Category: Yan CY]]
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[[Category: Metacaspase]]
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[[Category: Rossmann fold]]
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Current revision

Crystal structure of the yeast metacaspase Yca1 C276A mutant

PDB ID 4f6p

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