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3q90
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==Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1== | ==Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1== | ||
| - | <StructureSection load='3q90' size='340' side='right' caption='[[3q90]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='3q90' size='340' side='right'caption='[[3q90]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3q90]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3q90]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q90 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q90 OCA], [https://pdbe.org/3q90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q90 RCSB], [https://www.ebi.ac.uk/pdbsum/3q90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q90 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Ekblad | + | [[Category: Ekblad T]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Karlberg | + | [[Category: Karlberg T]] |
| - | [[Category: Kol | + | [[Category: Kol S]] |
| - | [[Category: Kotenyova | + | [[Category: Kotenyova T]] |
| - | [[Category: Kouznetsova | + | [[Category: Kouznetsova E]] |
| - | [[Category: Moche | + | [[Category: Moche M]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Nyman | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | + | [[Category: Schuler H]] | |
| - | [[Category: Schuler | + | [[Category: Schutz P]] |
| - | [[Category: Schutz | + | [[Category: Siponen MI]] |
| - | [[Category: Siponen | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Tresaugues L]] |
| - | [[Category: Tresaugues | + | [[Category: Van Der Berg S]] |
| - | [[Category: | + | [[Category: Wahlberg E]] |
| - | [[Category: | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Ekblad T | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson I | Karlberg T | Kol S | Kotenyova T | Kouznetsova E | Moche M | Nordlund P | Nyman T | Persson C | Schuler H | Schutz P | Siponen MI | Thorsell AG | Tresaugues L | Van Der Berg S | Wahlberg E | Weigelt J | Welin M
