3snm

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==Crystal structure of a lectin from Canavalia maritima seeds complexed with Indole-3-Acetic Acid==
==Crystal structure of a lectin from Canavalia maritima seeds complexed with Indole-3-Acetic Acid==
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<StructureSection load='3snm' size='340' side='right' caption='[[3snm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='3snm' size='340' side='right'caption='[[3snm]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3snm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_lineata Canavalia lineata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SNM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3snm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_lineata Canavalia lineata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SNM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3snm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3snm OCA], [http://pdbe.org/3snm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3snm RCSB], [http://www.ebi.ac.uk/pdbsum/3snm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3snm ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3snm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3snm OCA], [https://pdbe.org/3snm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3snm RCSB], [https://www.ebi.ac.uk/pdbsum/3snm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3snm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CONA_CANLI CONA_CANLI]] Glucose/D-mannose specific lectin.
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[https://www.uniprot.org/uniprot/CONA_CANLI CONA_CANLI] Glucose/D-mannose specific lectin.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Indole-3-acetic acid (IAA) bound is considered a storage molecule and is inactive. However, some studies have proposed an additional possible regulatory mechanism based on the ability of lectins to form complexes with IAA. We report the first crystal structure of ConM in complex with IAA at 2.15 A resolution. Based on a tetrameric model of the complex, we hypothesize how the lectin controls the availability of IAA during the early seedling stages, indicating a possible new physiological role for these proteins. A free indole group is also bound to the protein. The ConM interaction with different forms of IAA is a strategy to render the phytohormone unavailable to the cell. Thus, this new physiological role proposed for legume lectins might be a novel mechanism by which IAA levels are decreased in addition to the destruction and formation of new complexes in the later stages of seed germination.
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Interactions between indole-3-acetic acid (IAA) with a lectin from Canavalia maritima seeds reveal a new function for lectins in plant physiology.,Delatorre P, Silva-Filho JC, Rocha BA, Santi-Gadelha T, da Nobrega RB, Gadelha CA, do Nascimento KS, Nagano CS, Sampaio AH, Cavada BS Biochimie. 2013 Sep;95(9):1697-703. doi: 10.1016/j.biochi.2013.05.008. Epub 2013 , May 29. PMID:23727478<ref>PMID:23727478</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3snm" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Concanavalin A|Concanavalin A]]
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*[[Concanavalin 3D structures|Concanavalin 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Canavalia lineata]]
[[Category: Canavalia lineata]]
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[[Category: Alencar, K L]]
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[[Category: Large Structures]]
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[[Category: Cavada, B S]]
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[[Category: Alencar KL]]
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[[Category: Delatorre, P]]
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[[Category: Cavada BS]]
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[[Category: Gadelha, C A.A]]
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[[Category: Delatorre P]]
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[[Category: Nobrega, R B]]
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[[Category: Gadelha CAA]]
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[[Category: Rocha, B C]]
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[[Category: Nobrega RB]]
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[[Category: Santi-Gadelha, T]]
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[[Category: Rocha BC]]
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[[Category: Silva-Filho, J C]]
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[[Category: Santi-Gadelha T]]
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[[Category: Metal binding protein]]
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[[Category: Silva-Filho JC]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of a lectin from Canavalia maritima seeds complexed with Indole-3-Acetic Acid

PDB ID 3snm

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