3upn

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==Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex==
==Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex==
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<StructureSection load='3upn' size='340' side='right' caption='[[3upn]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3upn' size='340' side='right'caption='[[3upn]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3upn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UPN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3upn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UPN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM2:(5R)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-[(2-{[(E)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lo7|3lo7]], [[3un7|3un7]], [[3upo|3upo]], [[3upp|3upp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IM2:(5R)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-[(2-{[(E)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0019, MTCY10H4.16c, pbpA, Rv0016c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3upn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3upn OCA], [https://pdbe.org/3upn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3upn RCSB], [https://www.ebi.ac.uk/pdbsum/3upn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3upn ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3upn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3upn OCA], [http://pdbe.org/3upn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3upn RCSB], [http://www.ebi.ac.uk/pdbsum/3upn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3upn ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PBPA_MYCTU PBPA_MYCTU]] Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation.
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[https://www.uniprot.org/uniprot/PBPA_MYCTU PBPA_MYCTU] Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3upn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3upn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
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[[Category: Large Structures]]
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[[Category: Davies, C]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Fedorovich, A]]
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[[Category: Davies C]]
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[[Category: Beta-lactam]]
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[[Category: Fedorovich A]]
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[[Category: Penicillin-binding protein-antibiotic complex]]
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[[Category: Peptidoglycan]]
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[[Category: Transpeptidase]]
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Current revision

Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex

PDB ID 3upn

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