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4msp

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Current revision (10:05, 28 December 2022) (edit) (undo)
 
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==Crystal structure of human peptidyl-prolyl cis-trans isomerase FKBP22 (aka FKBP14) containing two EF-hand motifs==
==Crystal structure of human peptidyl-prolyl cis-trans isomerase FKBP22 (aka FKBP14) containing two EF-hand motifs==
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<StructureSection load='4msp' size='340' side='right' caption='[[4msp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4msp' size='340' side='right'caption='[[4msp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4msp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MSP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4msp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP14, FKBP22, UNQ322/PRO381 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4msp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msp OCA], [https://pdbe.org/4msp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4msp RCSB], [https://www.ebi.ac.uk/pdbsum/4msp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4msp ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4msp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msp OCA], [http://pdbe.org/4msp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4msp RCSB], [http://www.ebi.ac.uk/pdbsum/4msp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4msp ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FKB14_HUMAN FKB14_HUMAN]] Ehlers-Danlos syndrome, kyphoscoliotic and deafness type. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/FKB14_HUMAN FKB14_HUMAN] Ehlers-Danlos syndrome, kyphoscoliotic and deafness type. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FKB14_HUMAN FKB14_HUMAN]] PPIases accelerate the folding of proteins during protein synthesis.
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[https://www.uniprot.org/uniprot/FKB14_HUMAN FKB14_HUMAN] PPIases accelerate the folding of proteins during protein synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Bachinger, H P]]
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[[Category: Bachinger HP]]
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[[Category: Boudko, S P]]
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[[Category: Boudko SP]]
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[[Category: Ishikawa, Y]]
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[[Category: Ishikawa Y]]
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[[Category: Calcium binding]]
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[[Category: Ef-hand motif]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Fkbp-type domain]]
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[[Category: Isomerase]]
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[[Category: Peptidyl-prolyl cis-trans isomerase]]
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Current revision

Crystal structure of human peptidyl-prolyl cis-trans isomerase FKBP22 (aka FKBP14) containing two EF-hand motifs

PDB ID 4msp

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