3oxh
From Proteopedia
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==Mycobacterium tuberculosis kinase inhibitor homolog RV0577== | ==Mycobacterium tuberculosis kinase inhibitor homolog RV0577== | ||
| - | <StructureSection load='3oxh' size='340' side='right' caption='[[3oxh]], [[Resolution|resolution]] 1.75Å' scene=''> | + | <StructureSection load='3oxh' size='340' side='right'caption='[[3oxh]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3oxh]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3oxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OXH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PMB:PARA-MERCURY-BENZENESULFONIC+ACID'>PMB</scene>, <scene name='pdbligand=XYL:D-XYLITOL'>XYL</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PMB:PARA-MERCURY-BENZENESULFONIC+ACID'>PMB</scene>, <scene name='pdbligand=XYL:D-XYLITOL'>XYL</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oxh OCA], [https://pdbe.org/3oxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oxh RCSB], [https://www.ebi.ac.uk/pdbsum/3oxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oxh ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CFP32_MYCTU CFP32_MYCTU] May function as a glyoxylase involved in the methylglyoxal detoxification pathway (PubMed:20975714). Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL-12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses (PubMed:22415304).<ref>PMID:20975714</ref> <ref>PMID:22415304</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
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[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Alber T]] |
| - | [[Category: | + | [[Category: Echols N]] |
| + | [[Category: Flynn EM]] | ||
| + | [[Category: Ng H-L]] | ||
| + | [[Category: Stephenson S]] | ||
Current revision
Mycobacterium tuberculosis kinase inhibitor homolog RV0577
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