4qky

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==Crystal Structure Analysis of the Membrane Transporter FhaC==
==Crystal Structure Analysis of the Membrane Transporter FhaC==
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<StructureSection load='4qky' size='340' side='right' caption='[[4qky]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4qky' size='340' side='right'caption='[[4qky]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qky]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2qdz 2qdz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QKY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_pertussis_Tohama_I Bordetella pertussis Tohama I]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2qdz 2qdz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QKY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qdz|2qdz]], [[4ql0|4ql0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qky OCA], [http://pdbe.org/4qky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qky RCSB], [http://www.ebi.ac.uk/pdbsum/4qky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qky ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qky OCA], [https://pdbe.org/4qky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qky RCSB], [https://www.ebi.ac.uk/pdbsum/4qky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qky ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FHAC_BORPE FHAC_BORPE]] Member of a two partner secretion pathway (TPS) in which it mediates the secretion of filamentous hemagglutinin (FHA).<ref>PMID:16771844</ref>
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[https://www.uniprot.org/uniprot/FHAC_BORPE FHAC_BORPE] Member of a two partner secretion pathway (TPS) in which it mediates the secretion of filamentous hemagglutinin (FHA).<ref>PMID:16771844</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB) superfamily are essential components of protein transport machineries. The TpsB transporter FhaC mediates the secretion of Bordetella pertussis filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of FhaC. The transporter comprises a 16-stranded beta barrel that is occluded by an N-terminal alpha helix and an extracellular loop and a periplasmic module composed of two aligned polypeptide-transport-associated (POTRA) domains. Functional data reveal that FHA binds to the POTRA 1 domain via its N-terminal domain and likely translocates the adhesin-repeated motifs in an extended hairpin conformation, with folding occurring at the cell surface. General features of the mechanism obtained here are likely to apply throughout the superfamily.
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Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily.,Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V Science. 2007 Aug 17;317(5840):957-61. PMID:17702945<ref>PMID:17702945</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4qky" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Clantin, B]]
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[[Category: Bordetella pertussis Tohama I]]
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[[Category: Delattre, A S]]
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[[Category: Large Structures]]
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[[Category: Dewitte, F]]
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[[Category: Clantin B]]
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[[Category: Gruss, F]]
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[[Category: Delattre AS]]
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[[Category: Hiller, S]]
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[[Category: Dewitte F]]
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[[Category: Jacob-Dubuisson, F]]
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[[Category: Gruss F]]
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[[Category: Maier, T]]
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[[Category: Hiller S]]
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[[Category: Villeret, V]]
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[[Category: Jacob-Dubuisson F]]
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[[Category: Beta barrel]]
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[[Category: Maier T]]
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[[Category: Outer membrane]]
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[[Category: Villeret V]]
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[[Category: Potra domain]]
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[[Category: Protein transport]]
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Current revision

Crystal Structure Analysis of the Membrane Transporter FhaC

PDB ID 4qky

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