3c6e

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==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH==
==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH==
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<StructureSection load='3c6e' size='340' side='right' caption='[[3c6e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3c6e' size='340' side='right'caption='[[3c6e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3c6e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26] and [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C6E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3c6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Dengue_virus_2_Thailand/16681/84 Dengue virus 2 Thailand/16681/84]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C6E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c5x|3c5x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6e OCA], [http://pdbe.org/3c6e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c6e RCSB], [http://www.ebi.ac.uk/pdbsum/3c6e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c6e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6e OCA], [https://pdbe.org/3c6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c6e RCSB], [https://www.ebi.ac.uk/pdbsum/3c6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c6e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/O09234_DEN26 O09234_DEN26]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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[https://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Den26]]
 
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
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[[Category: Li, L]]
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[[Category: Dengue virus 2 Thailand/16681/84]]
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[[Category: Beta barrel]]
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[[Category: Large Structures]]
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[[Category: Helicase]]
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[[Category: Li L]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding]]
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[[Category: Prm-e protein complex structure]]
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[[Category: Rna replication]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH

PDB ID 3c6e

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