4lk2

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==Crystal structure of RNA splicing effector Prp5==
==Crystal structure of RNA splicing effector Prp5==
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<StructureSection load='4lk2' size='340' side='right' caption='[[4lk2]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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<StructureSection load='4lk2' size='340' side='right'caption='[[4lk2]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LK2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LK2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ljy|4ljy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRP5, RNA5, YBR237W, YBR1603 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lk2 OCA], [https://pdbe.org/4lk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4lk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lk2 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lk2 OCA], [http://pdbe.org/4lk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4lk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lk2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRP5_YEAST PRP5_YEAST]] ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.<ref>PMID:8405998</ref> <ref>PMID:8065365</ref> <ref>PMID:8969184</ref> <ref>PMID:8969185</ref> <ref>PMID:8622683</ref> <ref>PMID:11927574</ref> <ref>PMID:14610285</ref> <ref>PMID:16314500</ref>
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[https://www.uniprot.org/uniprot/PRP5_YEAST PRP5_YEAST] ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.<ref>PMID:8405998</ref> <ref>PMID:8065365</ref> <ref>PMID:8969184</ref> <ref>PMID:8969185</ref> <ref>PMID:8622683</ref> <ref>PMID:11927574</ref> <ref>PMID:14610285</ref> <ref>PMID:16314500</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: RNA helicase]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Xu, Y]]
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[[Category: Xu Y]]
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[[Category: Yang, F]]
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[[Category: Yang F]]
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[[Category: Zhang, Z M]]
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[[Category: Zhang Z-M]]
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[[Category: Zhou, J]]
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[[Category: Zhou J]]
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[[Category: Dead box family]]
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[[Category: Hydrolase]]
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[[Category: Prp5]]
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[[Category: Rna splicing]]
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Current revision

Crystal structure of RNA splicing effector Prp5

PDB ID 4lk2

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