3tzd

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==Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3)==
==Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3)==
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<StructureSection load='3tzd' size='340' side='right' caption='[[3tzd]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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<StructureSection load='3tzd' size='340' side='right'caption='[[3tzd]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tzd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZD FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H1E, H1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzd OCA], [http://pdbe.org/3tzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tzd RCSB], [http://www.ebi.ac.uk/pdbsum/3tzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzd OCA], [https://pdbe.org/3tzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzd RCSB], [https://www.ebi.ac.uk/pdbsum/3tzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN]] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. [[http://www.uniprot.org/uniprot/H14_HUMAN H14_HUMAN]] Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
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[https://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Amaya, M F]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Amaya MF]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Kozieradzki, I]]
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[[Category: Edwards AM]]
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[[Category: Loppnau, P]]
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[[Category: Kozieradzki I]]
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[[Category: Min, J]]
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[[Category: Loppnau P]]
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[[Category: Ouyang, H]]
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[[Category: Min J]]
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[[Category: Ravichandran, M]]
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[[Category: Ouyang H]]
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[[Category: Structural genomic]]
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[[Category: Ravichandran M]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Chromatin regulator]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Repressor]]
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[[Category: Sgc]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna binding protein complex]]
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Current revision

Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3)

PDB ID 3tzd

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OCA

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