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4b8e

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==PRY-SPRY domain of Trim25==
==PRY-SPRY domain of Trim25==
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<StructureSection load='4b8e' size='340' side='right' caption='[[4b8e]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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<StructureSection load='4b8e' size='340' side='right'caption='[[4b8e]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.779&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8e OCA], [http://pdbe.org/4b8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b8e RCSB], [http://www.ebi.ac.uk/pdbsum/4b8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8e ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8e OCA], [https://pdbe.org/4b8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8e RCSB], [https://www.ebi.ac.uk/pdbsum/4b8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRI25_MOUSE TRI25_MOUSE]] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).
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[https://www.uniprot.org/uniprot/TRI25_MOUSE TRI25_MOUSE] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Babon, J J]]
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[[Category: Mus musculus]]
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[[Category: Cruz, A A.D]]
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[[Category: Babon JJ]]
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[[Category: Kershaw, N J]]
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[[Category: D'Cruz AA]]
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[[Category: Nicholson, S E]]
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[[Category: Kershaw NJ]]
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[[Category: Nicola, N A]]
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[[Category: Nicholson SE]]
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[[Category: Ligase]]
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[[Category: Nicola NA]]

Current revision

PRY-SPRY domain of Trim25

PDB ID 4b8e

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