4m7l
From Proteopedia
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==Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment== | ==Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment== | ||
| - | <StructureSection load='4m7l' size='340' side='right' caption='[[4m7l]], [[Resolution|resolution]] 3.40Å' scene=''> | + | <StructureSection load='4m7l' size='340' side='right'caption='[[4m7l]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M7L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [https://pdbe.org/4m7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [https://www.ebi.ac.uk/pdbsum/4m7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref> |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Gilliland GL]] |
| - | [[Category: | + | [[Category: Malia T]] |
| - | [[Category: | + | [[Category: Obmolova G]] |
| + | [[Category: Teplyakov A]] | ||
Current revision
Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
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