3rx4

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==Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide==
==Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide==
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<StructureSection load='3rx4' size='340' side='right' caption='[[3rx4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3rx4' size='340' side='right'caption='[[3rx4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RX4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SFI:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFANYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SFI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rx2|3rx2]], [[3rx3|3rx3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SFI:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFANYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SFI</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx4 OCA], [https://pdbe.org/3rx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rx4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx4 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx4 OCA], [http://pdbe.org/3rx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rx4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx4 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Aldose Reductase|Aldose Reductase]]
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Chen, J]]
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[[Category: Chen J]]
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[[Category: Hu, X]]
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[[Category: Hu X]]
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[[Category: Luo, H]]
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[[Category: Luo H]]
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[[Category: Zheng, X]]
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[[Category: Zheng X]]
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[[Category: Aldose reductase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide

PDB ID 3rx4

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