This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4m18

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:30, 20 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)==
==Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)==
-
<StructureSection load='4m18' size='340' side='right' caption='[[4m18]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
+
<StructureSection load='4m18' size='340' side='right'caption='[[4m18]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4m18]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M18 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4m18]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M18 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.203&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m17|4m17]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">COLEC7, PSPD, SFTP4, SFTPD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m18 OCA], [https://pdbe.org/4m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m18 RCSB], [https://www.ebi.ac.uk/pdbsum/4m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m18 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m18 OCA], [http://pdbe.org/4m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m18 RCSB], [http://www.ebi.ac.uk/pdbsum/4m18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m18 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN]] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
+
[https://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Allen, K]]
+
[[Category: Large Structures]]
-
[[Category: Cafarella, T R]]
+
[[Category: Allen K]]
-
[[Category: Calin, O]]
+
[[Category: Cafarella TR]]
-
[[Category: Crouch, E C]]
+
[[Category: Calin O]]
-
[[Category: Goh, B C]]
+
[[Category: Crouch EC]]
-
[[Category: Hartshorn, K L]]
+
[[Category: Goh BC]]
-
[[Category: Rynkiewicz, M J]]
+
[[Category: Hartshorn KL]]
-
[[Category: Schulten, K]]
+
[[Category: Rynkiewicz MJ]]
-
[[Category: Seaton, B A]]
+
[[Category: Schulten K]]
-
[[Category: Seeberger, P H]]
+
[[Category: Seaton BA]]
-
[[Category: White, M R]]
+
[[Category: Seeberger PH]]
-
[[Category: Carbohydrate recognition domain]]
+
[[Category: White MR]]
-
[[Category: Lectin]]
+
-
[[Category: Sugar binding protein]]
+
-
[[Category: Surfactant protein]]
+

Current revision

Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)

PDB ID 4m18

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4m18"
Personal tools